They have released material for bands such as his own, NOFX, Descendents, Me First and the Gimme Gimmes, Propagandhi, Rise Against, Lagwagon, Strung Out, No Use for a Name, Less Than Jake, Against Me!, Anti-Flag, and more.
One somewhat unique and defining characteristic of Fat Wreck Chords is that they only sign one-record deals with bands. This allows the bands working with Fat Wreck Chords to have a choice as to when and if they want to put a record out on the label. In some cases, bands have released albums on Fat Wreck Chords but also on other labels.
Many bands on this label participated in the campaign Punkvoter, which was started by Fat Mike and attempted to encourage the youth in the U.S. to vote against George W. Bush in the 2004 U.S. presidential election.
The label has had two subsidiaries over the years, Honest Don's and Pink & Black. Honest Don's released records from Diesel Boy, Chixdiggit, and Teen Idols amongst others, while Pink & Black released albums from female-fronted bands like Fabulous Disaster and Dance Hall Crashers.
Fat Mike also advanced $50,000 to Chris Hannah and Jord Samolesky of Propagandhi which he recouped within months from sales of Propagandhi records to help them start up their own label, G7 Welcoming Committee, though G7WC is independent from Fat Wreck.